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KMID : 0606920160240010075
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Biomolecules & Therapeutics
2016 Volume.24 No. 1 p.75 ~ p.84
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Rosmarinic Acid Attenuates Cell Damage against UVB Radiation-Induced Oxidative Stress via Enhancing Antioxidant Effects in Human HaCaT Cells
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Fernando Pattage Madushan Dilhara Jayatissa
Kang Kyoung Ah
Ryu Yea Seong
Chae Sung-Wook
Piao Mei Jing
Ryu Yea-Seong
Hewage Susara Ruwan Kumara Madduma
Hyun Jin-Won
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Abstract
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This study was designed to investigate the cytoprotective effect of rosmarinic acid (RA) on ultraviolet B (UVB)-induced oxidative stress in HaCaT keratinocytes. RA exerted a significant cytoprotective effect by scavenging intracellular ROS induced by UVB. RA also attenuated UVB-induced oxidative macromolecular damage, including protein carbonyl content, DNA strand breaks, and the level of 8-isoprostane. Furthermore, RA increased the expression and activity of superoxide dismutase, catalase, heme oxygenase-1, and their transcription factor Nrf2, which are decreased by UVB radiation. Collectively, these data indicate that RA can provide substantial cytoprotection against the adverse effects of UVB radiation by modulating cellular antioxidant systems, and has potential to be developed as a medical agent for ROS-induced skin diseases.
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KEYWORD
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Antioxidant system, Oxidative stress, Reactive oxygen species, Rosmarinic acid, Ultraviolet B
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